The FA Cup second-round draw paired 2021 champions Leicester City with non-league Dover Athletic. Seventh-tier Wimborne Town, fresh off a 2-0 victory over League Two Crawley, will host League One Bradford City at home. Bradford advanced with a 7-0 win over Marine FC and enters as heavy favorites despite Wimborne's underdog status in their first-ever second-round appearance.

Other notable pairings include seventh-tier Guiseley hosting League One Notts County after their 1-0 upset of National League Sutton United, and fifth-tier Kidderminster Harriers traveling to Barrow following a 3-0 demolition of League One Doncaster. All-League One matchups see Wigan Athletic face Barnsley, while Grimsby Town play Oldham Athletic after narrowly escaping Stafford Rangers on penalties.

The 20 second-round fixtures take place December 5-6, with the third-round draw scheduled for Monday, December 7. Premier League and Championship teams enter the competition in the third round.